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Bromocriptine administration reduces hyperphagia and adiposity and differentially affects Dopamine D2 receptor and transporter binding in leptin-receptor-deficient zucker rats and rats with diet-induced obesity

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Study 2: Selective Small-Molecule Inhibitors (including 5-Amino-1MQ) A selective, membrane-permeable NNMT inhibitor series decreased intracellular 1-MNA, increased NAD and SAM, suppressed adipocyte lipogenesis, and reversed high-fat-diet obesity in mice